Extractive Spectrophotometric Determination of Nisoldipine by Ion-pair Complex Formation

Nisoldipine, a 1-4-dihydropyridine drug is determined by the development of simple and sensitive Extractive Spectrophotometric method. In the present study an ion-pair complex of amino derivative of the Nisoldipine with Bromocresol Green Solution in acidic medium is formed with subsequent extraction of the ion-pair complex in Chloroform. Maximum absorption was seen at the wavelength of 418 nm that obeys the Beer’s law in the concentration range of 5-25 μg/ml.All the variables were cautiously studied and optimised. International Conference of Harmonization guidelines were strictly followed for the validation of analytical performance of the method. Drugs in commercial tablets were determined by applying the suggested method. Results also compared statistically with the reference method.